Dr. Ely - C.V.
CURRICULUM VITAE
STEPHEN W. ELY, PH.D., M.D.
ADDRESS:
257 McDowell Street
Asheville, NC 28803
Phone: (828) 258-1121
Fax: (828) 252-6114
EDUCATION:
Western Michigan University, Kalamazoo
Bachelor of Science, 1974
Michigan State University, East Lansing
Master of Science, Physiology, 1977
Ph.D., Physiology, 1980
University of Virginia, School of Medicine, Charlottesville
Doctor of Medicine, 1986
RESEARCH TRAINING:
1980 – 1981:NIH Fellow in cardiovascular Physiology with John Chimoskey, M.D.
Department of Physiology, Michigan State University, East Lansing
1981 – 1983NIH Fellow in Cardiovascular Physiology with Robert M. Berne, M.D.
Department of Physiology, University of Virginia, Charlottesville
SURGICAL TRAINING:
1986 – 1987Intern, Department of Surgery, University of Virginia Health Sciences Center
1987 – 1989Resident, Department of Surgery, University of Virginia Health Sciences Center
1989 – 1990Chief Resident, General Surgery, University of Virginia Health Sciences Center
1990 – 1991Fellow in Surgical Research, University of Virginia Health Sciences Center
1991 – 1993Resident in Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center
POSITIONS HELD:
1986 – 1993Research Assistant Professor, Department of Physiology, University of Virginia
1993 - presentAsheville Heart, Asheville, NC
1993 – presentAttending Surgeon, Mission Hospitals, Asheville, NC
1996Chief of Surgery, Mission Hospitals, Asheville, NC
1997 – presentDirector of Cardiac Surgical Services, Mission Hospitals, Asheville, NC
1997 – presentCo-Director of Heart Services, Mission Hospitals, Asheville, NC
2010 – presentPresident, Asheville Heart, PA, Asheville, NC
MEDICAL LICENSES: DATE ISSUED
State of Virginia1987
State of North Carolina1993
BOARD CERTIFICATION:DATE ISSUED
American Board of Surgery1994
American Board of Thoracic Surgery1995 & 2005
SOCIETY MEMBERSHIPS:
American Physiological Society
American Heart Association
North Carolina Medical Society
Buncombe County Medical Society
Fellow American of College of Surgeons
Society of Thoracic Surgeons
EXTRAMURAL FUNDING:
American Heart Association, Virginia Affiliate
Principle Investigator, July 1981 to June 1982.
Adenosine and coronary blood flow in conscious dogs.
National Institutes of Health, April 1982 to March 1983
National Research Service Awards 1F32-HL06523
Adenosine and the pathophysiologic coronary circulation.
American Heart Association, Virginia Affiliate
Collaborating Investigator with R.M. Mentzer, M.D., 1983-85
Adenine nucleotide repletion after myocardial ischemia.
National Institutes of Health, 1985-88
Collaborating Investigator with R.M. Mentzer, M.D., R01-HL03579
Adenosine enhanced myocardial protection during surgery.
HONORS AND AWARDS:
FORD Prize for research in pediatric cardiovascular disease
University of Virginia, 1988
Alpha Omega Alpha, Honor Medical Society, 1989
U.S. Patent #4,880,783. Granted November 14, 1989
Use of adenosine, hypoxanthine and ribose for improved protection of the heart during surgery
James Kindred Teaching Award
University of Virginia Medical School Class of 1990
Invited Speaker: Symposium on Myocardial Ischemia
Texas Heart Institute, Houston, Texas, September 1992.
BIBLIOGRAPHY
STEPHEN W. ELY, M.D.
CHAPTERS IN BOOKS:
1.Berne RM, Ely SW, Knabb RM, Bacchus AN, Rubio R. Local regulation of coronary blood flow. In: Calcium Entry Blocker, Adenosine and Neurohumors. Eds: GF Merrill, HR Weiss, A Scriabine. Urban and Schwarzenburg, Baltimore, 1983.
2.Berne RM, Winn HR, Knabb RM, Ely SW, Rubio, R. Local regulation by adenosine in heart, brain and skeletal muscle. In: Regulatory Functions of Adenosine. Eds: RM Berne, TW Rall, R Rubio. Martinus Nijhoff Publishers, Hingham, MA, 1983.
3.Rubio R., Knabb RM, Ely SW, Berne RM. A critique of the use of adenosine deaminase to test the adenosine hypothesis: Disregarded implicit assumptions. In: Topics and Perspectives in Adenosine Research. Springer-Verlag, Berlin, 1987.
PRESENTATIONS:
American Physiological Society, Fall Meetings, Hollywood Beach, Florida. October 1977
Federation of American Society for Experimental Biology, Dallas, Texas. April 1979.
American Physiological Society, Fall Meetings, New Orleans, Louisiana. October 1979
American Physiological Society, Fall Meetings, Toronto, Ontario. October 1980.
American Heart Association, Scientific Sessions, Dallas, Texas. November 1981.
International Symposium on Adenosine, Charlottesville, Virginia. June 1982.
American Heart Association, Scientific Sessions, Dallas, Texas. November 1982.
International Symposium on Myocardial Protection, Boston, Massachusetts. May 1985.
American Heart Association, Scientific Sessions, Washington, D.C. November, 1985.
American Physiological Society, Fall Meetings, San Diego, California. October 1987.
American Heart Association, Scientific Sessions, Dallas, Texas. November, 1990.
Federation of the American Societies for Experimental Biology, Atlanta, Georgia. April 1991.
American College of Cardiology, Dallas, Texas. April 1992.
MANUSCRIPTS:
1.Ely SW, Sawyer DC, Anderson DL, Scott JB. Carotid sinus reflex vasoconstriction in the right coronary circulation of dog and pig. Am. J. Physiol. 241:H149-H154, 1981.
2.Ely SW, Sawyer DC, Anderson DL, Scott JB. Local vasoactivity O2 and CO2 in the right coronary circulation of dog and pig. J. Physiol. (London) 332:427-438, 1982.
3. Chimoskey JE, Breuhaus BA, Ely SW. Hemodynamics of high afterload left heart failure for assist device testing. Biomat. Med. Deve. Artificial Organs 10:267-279, 1982.
4.Chimoskey JE, Breuhaus BA, Ely SW. Cardiac and sinoaortic reflexes during aortic constriction in awake calves. Biomat. Med. Dev. Artificial Organs 11:175-195, 1983.
5.Valkner K, Ely SW, Scott JB, Bieber LL. Effect of anoxia and hypoxia of rat and pig heart short chain acylcarnitines. Comp. Biochem. Physio. 80:123-127, 1985.
6.Bacchus AN, Ely SW, Knabb RM, Rubio R, Berne RM. Adenosine and coronary blood flow in conscious dogs during normal physiologic stimuli. Am. J. Physiol. 243:H628-H633, 1983.
7.Ely WS, Knabb RM, Bacchus AN, Rubio R, Berne RM. Measurements of coronary plasma and pericardial infusate adenosine concentrations during exercise in the conscious dog: Relationship to myocardial oxygen consumption and coronary blood flow. J. Mol. Cell. Cardiol. 15:673-683, 1983.
8.Berne RM, Ely SW, Knabb RM, Bacchus AN, Rubio R. Local regulation of coronary blood flow in normoxia. Fed. Proc. 42:3136-3142, 1983.
9.Knabb RM, Ely SW, Bacchus AN, Rubio R., Berne RM. Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions in the dog. Circ. Res. 53:33-41, 1983.
10.Ely SW, Sun CW, Knabb RM, Gidday JM, Rubio R, Berne RM. Adenosine and regulation of coronary blood flow in dogs with renal hypertension. Hypertension 5:943-950, 1983.
11.Knabb RM, Gidday JM, Ely SW, Rubio R, Berne RM. Effects of dipyridamole on myocardial adenosine and active hyperemia. Am. J. Physiol. 247:H804-H810, 1984
12.Mentzer RM, Ely SW, Lasley RD, Mainwaring RD, Wright EM, Berne RM. Hormonal role of adenosine in maintaining the patency of the ductus arteriosus in fetal lambs. Ann Surg. 202:223-230, 1985.
13.Ely WS, Mentzer RM, Lasley RD, Lee BK, Berne RM. Functional and metabolic evidence of enhanced myocardial tolerance to ischemia and reperfusion with adenosine. J. Thor. Cardiovasc. Surg. 90:549-556, 1985.
14.Mainwaring RD, Mentzer RM, Ely SW, Rubio R., Berne RM. The role of adenosine in the regulation of coronary blood flow in the newborn lamb. Surgery 98:540-545, 1985.
15.Walsh RS, Ely SW, Rubio R, Mentzer RM. The effect of nitroglycerin in the ductus arteriosus of fetal sheep. Surg. Forum 36:248,1985.
16.Mentzer RM, Ely SW, Lasley RD, Berne RM. The acute effects of AICAR on purine nucleotide metabolism and post-ischemic cardiac function. J. Thor. Cardiovas. Surg. 95:286-293, 1988.
17.Lasley RD, Ely SW, Berne RM, Mentzer RM. Allopurinol enhanced adenine nucleotide repletion following myocardial ischemia. J. Clinical Investigation 81:16-20, 1988.
18.Walsh RS, Ely SW, Mentzer RM Response of lamb ductus arteriosus to nitroglycerin and nitroprusside. J. Surg. Res. 44:8-13, 1988.
19.Mainwaring RD, Ely SW, Mentzer RM. Myocardial reactive hyperemia in the newborn. J. Surg. Res. 44:603-608, 1988.
20.Wyatt DA, Ely SW, Lasley RD, Walsh RS, Mainwaring RD, Berne RM, Mentzer RM. Purine enriched assanguinous cardioplegia regards ischemic ATP degradation and improves post-ischemic ventricular function. J. Thor. Cardiovasc. Surg. 97:771-778, 1989.
21.Gidday JM, Esther JW, Ely SW, Rubio R, Berne RM. Time-dependent effects of theophylline on myocardial reactive hyperemia in the anesthetized dog. British J. Pharmacology. 100:95-101, 1990.
22.Matherne GP, Headrick JP, Ely SW, Coleman SD, Berne RM. Changes in work rate to oxygen consumption ratio during hypoxia and ischemia in immature and mature rabbit hearts. J. Mol. Cell. Cardiol. 24:1409-1421, 1992.
23.Ely SW, Berne RM. Protective effects of adenosine in myocardial ischemia. Circulation 85:893-904, 1992.
24.Ely SW, Matherne GP, Coleman, SP, Berne RM. Inhibition of adenosine metabolism increases interstitial adenosine concentrations and coronary flow. J. Mol. Cell. Cardiol. 24:1321-1332, 1992.
25.Ely SW Kron, IL. Thoracoscopic AICD implantation. Chest 103:271-272, 1993.
26.Headrick JP, Ely SW, Matherne GP, Berne RM. Myocardial adenosine, flow, and metabolism during adenosine antagonism and adrenergic stimulation. Am. J. Physiol. 264:H61-H70, 1993.
27. Groh MA, Sutherland SE, Burton HG, Johnson AM, Ely SW: Port access coronary artery bypass grafting: Technique and comparative results. Ann Thorac Surg 68:1506-1508, 1999.
28.Groh MA, Binns OAR, Burton HG, Ely SW, Johnson AM: Ultrasonic Cardiac Ablation for Atrial Fibrillation During Concomitant Cardiac Surgery: Long-Term Clinical Outcomes. Ann Thorac Surg. 84: 1978-1983, 2007.
29.Groh MA, Binns OAR, Burton HG, Champsaur G, Ely SW, Johnson AM: Epicardial Ultrasonic Ablation of Atrial Fibrillation During Concomitant Cardiac Surgery is a Valid Option in Patients with Ischemic Heart Disease. Circulation. 118: S78-S82, 2008.
ABSTRACTS
1.Scott JB, Nyhof R, Anderson D, Swindall B, Ely S, Haddy F. Possible explanation for failure of theophylline to block hypoxic coronary dilatation. Fed. Proc. 34:415, 1979.
2.Ely SW, Maier MC, Underwood RS, Emerson TE. Changes in regional cerebral blood flows during chronic experimental renovascular hypertension in the dog. Physiologist 20:25, 1977.
3.Maier MC, Ely SW, Emerson TD. Regional vascular responses to angiotensin II in the splanchnic circulation. Fed. Proc. 37:803, 1977.
4.Eyster GE, Gonzalez-Levin L, Ely, SW, DeYoung B. Hemodynamic evaluation of atrial-pulmonary bypass. Eight Annual Michigan Cardiovascular Research Forum 8:38, 1978.
5.Ely SW, Scott JB. Interaction of flow and neurohumerol factors in the regulation of the right coronary circulation. Fed. Proc. 38:955, 1979.
6.Ely SW, Scott, JB. Effects of indomethacin and hyperventilation on the response of the right coronary circulation to norepinephrine and sympathetic stimulation. Clin. Res. 27:163A, 1979.
7.Ely SW, Korthuis R, Sawyer DC, Scott, JB. Effects of local hypoxia and hypocapnia on the response of the right coronary circulation to sympathetic stimulation. Physiologist 22:34, 1979.
8.Sawyer DC, Ely SW, Korthuis R, Scott, JB. Effects of halothane on the right coronary circulation in the dog. Proc. Internat. Anesth. Res. Soc. March 13, 1980.
9.Scott JB, Ely SW, Anderson DL, Sawyer D. Effect of an endoperoxide analogue in right coronary blood flow in the pig. Physiologist 23:6, 1980.
10.Sawyer DC, Ely SW, Scott JB. Halothane and ethrane effects on the coronary circulation. Anesthesiology, September 1980.
11.Ely SW, Anderson D., Sawyer D., Scott JB. Effect of morphine sulphate on right coronary blood flow in the pig. Proc. 10th Ann. Michigan Cardiovascular Forum, September, 1980.
12.Ely SW, Chimoskey JE. Left heart failure model for testing assist devices. Proc. Ann Contract Meeting, Devices and Tech. Branch, NHLBI, December 1980.
13.Cameron TS, Ely SW, Chimoskey JE. Production of left ventricular failure by intracoronary infusion of lidocaine in anesthetized sheep. Proc. Ann. Contractors Meeting, Devices and Tech. Branch, NHLBI, December 1980.
14.Ely SW, Bacchus AN, Knabb R, Rubio R, Berne RM. Myocardial adenosine release during treadmill exercise in the conscious dog. Physiologist 24:82, 1981.
15.Knabb R, Ely S, Bacchus A, Rubio R, Berne R. Changes in myocardial oxygen consumption and adenosine production with alterations in heart rate. Physiologist 24:82, 1981.
16.Chimoskey JE, Ely SW. Systemic and renal hemodynamic response to left ventricular failure, carotid occlusion, and vagal block in conscious calves. Physiologist 24:110, 1981.
17.Ely SW, Bacchus A, Knabb R, Rubio R, Berne R. Evidence for the involvement of adenosine in the regulation of coronary blood flow during exercise in the conscious dog. Circulation 64:267, 1981.
18.Ely SW, Chimoskey JE. Cardiopulmonary baroreflex influence on the renal circulation during left heart failure in conscious calves. Circulation 64:156, 1981.
19.Rubio R, Knabb R, Ely S, Berne R. Fifty percent decrease in the coronary flow response to hypoxia by “micro” adenosine deaminases. Fed. Proc. 41:1599, 1982.
20.Knabb R, Ely S, Tayal V, Rubio R, Berne R. Myocardial adenosine production with increased oxygen consumption: Effect of receptor stimulation and blockade. Fed. Proc. 41:1529, 1982.
21.Ely SW, Knabb RM, Sun CW, Gidday JM, Tayal VS, Rubio R, Berne RM. Metabolic regulation of coronary blood flow in the hypertensive dog. Circulation 66:II-155, 1982.
22.Knabb RM, Ely SW, Rubio R, Berne RM. Effects of dipyridamole on relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine. In: The Regulatory Functions of Adenosine. Eds: RM Berne, TW Rall, R Rubio. Martinus Nijhoff Publishers, 1983.
23.Rubio R, Knabb R, Ely SW, Berne RM. The use of a “micro” adenosine deaminase to elucidate the functional significance and tissue distribution of adenosine. In: The Regulatory Functions of Adenosine. Eds: RM Berne, TW Rall, R Rubio. Martinus Nijhoff Publishers, 1983.
24.Ely SW, Knabb RM, Sun CW, Gidday J, Rubio R, Berne RM. Role of adenosine in the regulation of coronary blood flow in the hypertensive dog. In: The Regulatory Functions of Adenosine. Ed: RM Berne, TW Rall, R Rubio. Martin Nijhoff Publishers, 1983.
25.Knabb R, Gidday J, Ely S, Rubio R, Berne RM. Effects of dipyridamole on pericardial infusate and coronary plasma adenosine. Fed. Proc. 42:462, 1983.
26.Malloy LG, Ely SW, Rubio R, Berne RM. Differential effects of adenosine infusion on vascular resistance in red and white skeletal muscle. Fed. Proc. 42:747, 1983.
27.Mentzer RM, Ely SW, Lasley RD, Wright EM, Berne RM. Effects of adenosine on ductus arteriosus. Cir. 68:III-269, 1983.
28.Gidday J, Ely S, Esther J, Berne R. Progressive attenuation of coronary reactive hyperemia with increasing interstitial theophylline permeation. Fed. Proc. 43:1084, 1984.
29.Malloy LG, Hollinsead PS, Esther J, Ely SW, Berne RM. Minimum resistance produced by adenosine plus nitroprusside differs between red and white skeletal muscle. Fed. Proc. 43:537, 1984.
30.Mentzer, RM, Ely SW, Lasley RD, Lee BK, Berne RM Role of 5-adminoimidazole carboxyamide riboside (AICAR) in substrate enhancement of the post-ischemic myocardial nucleotide pool. Fed. Proc. 43:903, 1984.
31.Lasley RD, Ely SW, Berne RM, Mentzer RM. Allopurinol enhanced nucleotide repletion following myocardial ischemia. Fed. Proc. 44:636, 1985.
32.Mainwaring, RD, Mentzer RM, Ely SW, Berne RM. The role of adenosine in the regulation of coronary blood flow in newborn lambs. Proc. Soc. Univ. Surg. p142, 1985.
33.Ely SW, Mentzer RM, Lasley RD, Lee BK, Berne RM. Improvement in post-ischemic myocardial ATP repletion and recovery of ventricular function with adenosine. Proc. Internat. Symposium on Myocardial Protection, p58, 1985.
34. Ely SW, Lasley RD, Berne RM, Mentzer RM. Adenosine enhances myocardial tolerance to normothermic global ischemia. Circ. 72:III-349, 1985.
35.Walsh, RS, Ely SW, Rubio R, Berne RM, Mentzer RM. Nitroprusside relaxes ductus arteriosus in vitro. Fed. Proc. 45:879, 1986.
36.Lasley RD, Wellons JK, Ely SW, Berne RM, Mentzer RM. Purine salvage enhanced adenine nucleotide repletion following myocardial ischemia. Fed. Proc. 45:1038, 1986.
37.Mentzer RM, Ely SW, Lasley RD, Berne RM. Purine treatment during ischemia improves post-ischemic myocardial function. Third Internat. Symp. On Adenosine. Munich, 1986.
38.Brown JY, Lasley RD, Ely SW, Berne RM, Mentzer RM. Augmentation of endogenous adenosine improves post-ischemic myocardial function. Third Internat. Symp. on Adenosine, Munich, 1986.
39.Brown JY, Lasley RD, Ely SW, Berne RM, Mentzer RM. Inhibition of adenosine catabolism improves post-ischemic myocardial function. Circulation 74:II-358, 1986.
40.Wyatt DA, Ely SW, Rubio R, Berne RM, Mentzer RM. Adenosine stimulates glycolysis in normoxic myocardium. Circulation 74:II-433, 1986.
41.Walsh RS, Ely SW, Rubio R, Berne RM, Mentzer RM. Adenosine increases the tolerance of the immature rabbit myocardium to ischemia. Circulation 74:II-493, 1986.
42.Walsh RD, Ely SW, Rubio R, Berne RM, Mentzer RM. Adenosine increases the tolerance of the myocardium to ischemia. Proc. Soc. Univ. Surgeons, 1987.
43.Wyatt DA, Ely SW, Lasley RD, Mentzer RM. Purine enriched assanguinous cardioplegia provides superior myocardial protection. Surgical Forum, 1987.
44.Ely SW, Wyatt DA, Lasley RD, Mainwaring RD, Walsh RS, Berne RM, Mentzer RM. Use of purines to limit ischemic myocardial ATP degradation and promote post-ischemic myocardial function. Physiologist, August 1987.
45.Ely SW, Detmer DE, Kron IL, Daniel TM. Use of the supraclavicular approach for surgical treatment of thoracic outlet syndrome. Proc. Virginia Surgical Society, May 4-6, 1990.
46.Matherne GP, Headrick JP, Ely SW, Coleman SD, Berne RM. Effects of norepinephrine on interstitial adenosine in isolated hearts. FASEB J. 5:A693, 1991.
47.Ely SW, Headrick JP, Matherne GP, Berne RM. Increased interstitial adenosine formation in isolated hearts with 8 Phenyltheophylline. FASEB J. 5:A693, 1991.
48.Matherne GP, Headrick JP, Ely SW, Coleman SD, Berne RM. Changes in myocardial efficiency during hypoxia and ischemia in immature and mature rabbits hearts. J. Ped. Res. (in press)
49.Ely SW, Tribble CT, Linden J, Berne RM. Adenosine concentrations in normal and ischemic regions of the human myocardium. J. Am. Coll. Cardiol. 19:191A, 1992.